56Toxin-mediated Diseases – Staphilococcus Infection

56Toxin-mediated Diseases – Staphilococcus Infection


What kind of other diseases do these cause They cause staphylococcal scalded skin syndrome try and say that four times quickly This is a skin illness as you can see here and I think the name tells you what it looks like this mainly affects neonates This is caused by sloughing of the skin The skin is coming off It’s red and angry looking caused by toxins produced by the staphylococci specifically exfoliative toxins A and B Exfoliation, the
loss of your skin You can also describe a disease called toxic shock syndrome TSS which became popular not very long ago This is accompanied by fever, skin rash, hypotension low blood pressure and also peeling of the skin, exfoliation Toxic shock syndrome was first described in connection with the use of highly absorbent tampons that allowed organisms to proliferate Now tampons went through a revolution in their production where they became extremely absorbent and also would block off the vaginal canal and the makers thought this was a great thing because it’s convenient for women but it turned out that these trapped the staph bacteria in the vaginal canal allowed them to proliferate in and around the tampon and elaborate toxins and this brand-new disease that had never
been seen before toxic shock syndrome suddenly was described and that’s a staphylococcal
disease Associated initially with the use of tampons but now we know there are other causes as well One of the main toxins produced by staphylococci that causes toxic shock is called TSST-1 toxic shock syndrome toxin number one and this is an enterotoxin It actually acts as a super antigen Super antigens bind the T cell receptor and
the major histocompatibility protein on the surface of cells and cause massive release of cytokines from macrophages and T cells that are then responsible for the symptoms say of toxic shock syndrome The whole idea of toxic shock elaborates from these cytotoxins that are produced Staphylococci can also cause food poisoning we’ve been talking about skin diseases of various sorts but they can also be in your food and they produce enterotoxins that are in the food when you eat it, these make you sick The bacteria if they contaminate the food and you can imagine that someone may have staph aureus on their hands they’re preparing food, they haven’t washed their hands they don’t wear gloves, you now have staph aureus in the food, if it’s not kept cold if it’s at room temperature which sometimes happens during food production or serving the bacteria will grow, they will produce their toxins and when you eat it, you will get sick This typically happens with meats including poultry, egg products, salads, milk and dairy products So if you ever have been to a buffet where there is lots of food spread out on the table if it sits there for hours at room temperature the bacteria can grow and make their toxins Next time you go to such a function, make
sure the people are wearing gloves if they are not, you should just stick with the wine and don’t touch the food This disease, when you ingest these toxins causes nausea, vomiting, stomach cramps and diarrhea and it’s typically a rather rapid
onset So food poisoning where you are eating food that has a toxin in it already, the onset is quick So if you eat something and in an hour or
two later you’re vomiting you can say well that could be a staph aureus toxin caused food poisoning In contrast, if it takes a few days to get
sick that means the bacteria have to replicate in you before you get sick So this is a rapid onset food poisoning caused by staphylococci and then in two or three days you recover

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